Top-down proteomics: Difference between revisions
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| | |def=Method of protein identification that uses the ''[[m/z]]'' selection of intact proteins followed by fragmentation and ''m/z'' separation in a second stage of [[mass spectrometry]]. Mixtures of proteins must first be separated by [[wikipedia:high-performance liquid chromatography|liquid chromatography]] or other separation method prior to analysis by mass spectrometry. | ||
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|ref=S. K. Sze, Y. Ge, H. Oh, F. W. McLafferty. Proc. Natl. Acad. Sci. USA 99, 1774 (2002). (http://dx.doi.org/10.1073/pnas.251691898 ) | |||
N. L. Kelleher. Anal. Chem. 76, 197A (2004). (http://dx.doi.org/10.1021/ac0415657 ) | |||
}} | }} | ||
[[Category:Proteomics]] | |||
{{ext}}10.1007/s13361-019-02201-x F. Lermyte, Y.O. Tsybin, P.B. O'Connor, J.A. Loo, Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches, J Am Soc Mass Spectrom (2019) | |||
Latest revision as of 13:47, 22 March 2021
| IUPAC RECOMMENDATIONS 2013 |
| Top-down proteomics |
|---|
| Method of protein identification that uses the m/z selection of intact proteins followed by fragmentation and m/z separation in a second stage of mass spectrometry. Mixtures of proteins must first be separated by liquid chromatography or other separation method prior to analysis by mass spectrometry. |
| Related Term(s): |
| Reference(s):
S. K. Sze, Y. Ge, H. Oh, F. W. McLafferty. Proc. Natl. Acad. Sci. USA 99, 1774 (2002). (http://dx.doi.org/10.1073/pnas.251691898 ) N. L. Kelleher. Anal. Chem. 76, 197A (2004). (http://dx.doi.org/10.1021/ac0415657 ) |
| From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013. |
External links
- http://dx.doi.org/10.1007/s13361-019-02201-x F. Lermyte, Y.O. Tsybin, P.B. O'Connor, J.A. Loo, Top or Middle? Up or Down? Toward a Standard Lexicon for Protein Top-Down and Allied Mass Spectrometry Approaches, J Am Soc Mass Spectrom (2019)
