RSS:Mastadon

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[1]

(RSS) (RCM) An Efficient Solid Phase Extraction Method for Purification and Analysis of Compound‐Specific Plant Sugar Stable Hydrogen Isotope Values: ABSTRACT

Rationale

The stable hydrogen isotope composition (δ
2H) of plant compounds can serve as environmental or metabolic proxies, but interpretations are hindered by insufficient mechanistic understanding. This can be improved by analyzing the δ
2H values of metabolic… analyticalsciencejournals.onli

2025-10-29 09:03:08
[2]

(RSS) (RCM) Integrative Approach Based on DI‐MS and LC–MS/MS Analysis for Comprehensive Characterization of Flavonoid Glycoside Isomers From Onychopetalum periquino (Annonaceae): ABSTRACT

Rationale

Currently, mass spectrometry–based approaches constitute the primary strategy for the dereplication of flavonoid glycosides; however, strategies focused on the dereplication of their isomers are still scarce. On the other hand,… analyticalsciencejournals.onli

2025-10-29 08:21:37
[3]

(RSS) (BioRxiv All) Molecular characterisation of the acyltransferase-acyl carrier protein interface in a fungal highly reducing polyketide synthase.: Iterative polyketide synthases (iPKSs) rely on communication between acyl carrier protein (ACP) and acyltransferase (AT) domains to ensure efficient delivery of starter and extender substrates during biosynthesis. However, the molecular determinants governing the AT:ACP interface remain poorly… biorxiv.org/content/10.1101/20

2025-10-29 06:50:08
[4]

(RSS) (Proteom Res News) Does anyone know why there is a cockroach peptidomics paper every couple of years? New one!:  

I won't lie, I'm not even going to go past the first page on this one. I was at Johns Hopkins off and on for like 20 years. I have some cat sized cockroach related psychological trauma I've submerged that I'm not about to bring to the surface because someone decided to put an actual picture of how they get the… proteomicsnews.blogspot.com/20

2025-10-29 06:04:36
[5]

(RSS) (Proteom Res News) AlphaDIA - I don't understand why it is different but it IS open source!:  

I really did read the full body of the text for the published manuscript on AlphaDIA. I kept looking for the "why is this different than the DIA tools that I currently use" and I never had that "OH! That's why this is different!" moment. For real, WTF is a learning transfer? I'm either a poor reader or it is never fully explained in the… proteomicsnews.blogspot.com/20

2025-10-29 04:51:34
[6]

(RSS) (Proteom Res News) Pathogenic demo drops on Steam on Halloween!:  

Listen up gamer nerds. You can keep playing whatever dumb thing you are currently playing - or - hear me out - you can get a free demo for Pathogenic where you play as a pathogen trying to infect a host!! 

Demo goes live on halloween!  More info here. proteomicsnews.blogspot.com/20 (/Proteom Res News)

2025-10-29 03:47:35
[7]

(RSS) (JASMS) [ASAP] Investigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00211 dx.doi.org/10.1021/jasms.5c002 (RSS)

2025-10-29 03:28:34
[8]

(RSS) (JASMS) [ASAP] Development and Modification of Ion Mobility Mass Spectrometry Instrumentation for Enhanced Analysis of Biological Molecules: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00222 dx.doi.org/10.1021/jasms.5c002 (RSS)

2025-10-29 02:15:33
[9]

(RSS) (JASMS) [ASAP] Optimization of Data-Dependent Acquisition Parameters in Mass Spectrometry for Oligonucleotide Identification: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00250 dx.doi.org/10.1021/jasms.5c002 (RSS)

2025-10-29 01:18:13
[10]

(RSS) (JASMS) [ASAP] Quantification of Staphylococcal Enterotoxins by Coupling Laser-Induced Dissociation and Mass Spectrometry: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00261 dx.doi.org/10.1021/jasms.5c002 (RSS)

2025-10-29 00:05:33
[11]

(RSS) (BioRxiv All) Sideways lipid presentation by the antigen-presenting molecule CD1c: Here we report mass spectrometry analyses of endogenous lipids captured by CD1c when bound to an autoreactive abTCR. CD1c bound twenty-six lipids with bulky headgroups that could not fit within the tight TCR-CD1c interface. We determined the crystal structures of CD1c presenting several gangliosides, revealing a general mechanism whereby two lipids, rather than… biorxiv.org/content/10.1101/2...

2025-10-28 22:39:32
[12]

(RSS) (BioRxiv All) Effect of Lys84 carbamylation and chloride ion on OXA-143 dynamics and catalytic efficiency: Carbapenem-hydrolyzing Class-D {beta}-lactamase OXA-143 is known as an efficient carbapenemase, and the number of clinically isolated Acinetobacter baumannii carrying the OXA-143 gene has risen significantly since it was first identified in 2004. The inhibitory effect of chloride ions on OXA enzymes has been described in the literature;… biorxiv.org/content/10.1101/20...

2025-10-28 21:22:33
[13]

(RSS) (BioRxiv All) Type 1 LacNAc and LacdiNAc on N-glycans as molecular biomarkers of human melanoma cells: Melanoma, the most dangerous form of skin cancer, is characterized by its high potential to spread or metastasize. Tumor progression is associated with changes in glycosylation that occur early in carcinogenesis and evolve as the cancer develops and spreads. To identify new melanoma transformation markers, we analyzed N-glycans from… biorxiv.org/content/10.1101/20

2025-10-28 20:11:34
[14]

(RSS) (ABioanChem) A tunable analytical platform for bile acid isomers: from molecular recognition to pharmaceutical quality control: This study presents an innovative Trapped Ion Mobility Spectrometry-Mass Spectrometry (TIMS-MS) approach employing rifampicin (RFP) and Ba2+ coordination chemistry to address the analytical challenges posed by structurally similar bile acid (BA) isomers. Our methodology facilitates the formation of distinctive ternary… link.springer.com/article/10.1

2025-10-28 18:12:17
[15]

(RSS) (BioRxiv All) Integrated Multi-Omics Characterization of CDK4/hTERT-Immortalized Ovine Satellite Cells for Cultivated Meat Applications: Cultivated meat production requires stable, scalable cell lines that maintain essential biological characteristics. Here, we establish and comprehensively characterize CDK4/hTERT immortalized ovine satellite cells using flow cytometry-based isolation and integrated transcriptomic-proteomic analysis. Flow… biorxiv.org/content/10.1101/20

2025-10-28 13:03:34
[16]

(RSS) (J Proteom) Comparative quantitative proteomics of tumoral and peritumoral tissues for distinguishing human glioblastoma from low-grade astrocytoma: Publication date: Available online 27 October 2025

Source: Journal of Proteomics

Author(s): Zhigang Xiong, Chaoxi Li, Qiangqiang Han, Yanting Su, Liming Cheng, Hao-Long Zeng sciencedirect.com/science/arti

2025-10-28 12:13:33
[17]

(RSS) (BioRxiv All) Dynamic proteome profiling uncovers age-related impairments in proteostasis and the protective effects of resistance exercise in human skeletal muscle: A loss of proteostasis is a primary hallmark of ageing that has emerged from mechanistic studies in model organisms, but little is currently known about changes to proteostasis in the muscle of older humans. We used stable isotope labelling (deuterium oxide; D2O) in vivo, and… biorxiv.org/content/10.1101/20

2025-10-28 02:15:34
[18]

(RSS) (BioRxiv All) Refinement of locomotor activity is developmentally regulated by dopaminergic signaling in larval zebrafish: The refinement of gross motor skills, such as locomotion, during development is conserved across vertebrate species. Our previous work demonstrated, in larval zebrafish, that dopaminergic signaling through the dopamine D2-like family of receptors, specifically the dopamine 4 receptor subtype, was necessary for the… biorxiv.org/content/10.1101/20

2025-10-28 01:17:32
[19]

(RSS) (ACS Anal Chem) [ASAP] Comprehensive Internal Standards for Hydrogen–Deuterium Exchange Mass Spectrometry: Analytical ChemistryDOI: 10.1021/acs.analchem.5c05191 dx.doi.org/10.1021/acs.analche

2025-10-27 22:39:34
[20]

(RSS) Conserved hydrophilic checkpoints tune FocA-mediated formate:H+ symport nature.com/articles/s41467-025

2025-10-27 20:11:34
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