RSS:Analytical Chemistry

Analytical Chemistry

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[ASAP] Bottom–Up Protein Analysis Workflow for Simultaneous Characterization of Payloads, Disulfide Bonds, and Free Thiols in Antibody–Drug Conjugates

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05683

— Keting Zhou and Yu Xia 2025-12-16 11:43:18

[ASAP] NMR Spectral Alignment Utilizing a CryoEM Motion Correction Algorithm

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c02504

— Colin A. Hemme, Owen A. Warmuth, Songlin Wang, Christopher G. Williams, Alexander Thome, Leonard J. Mueller, Chad M. Rienstra, and Timothy Grant 2025-12-15 16:34:52

[ASAP] Raman Spectroscopy for In Vivo Tumor Imaging

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c03986

— Ying Bao, Liming Guo, Ziwen Gao, Yuting Yan, Yujie Duan, Yao Zhao, Hao Wang, and Chunsheng Xiao 2025-12-15 15:59:19

[ASAP] AnnoTCM: An Annotation Tool for Multimodal Metabolite–Phenotype Integration in Decoding Bioactive Compounds of Traditional Chinese Medicine

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04126

— Xingyi Liang, Yixin Cui, Yanwei Tan, Yang Zhou, Xingzu Cao, Zhe Wu, Chunling Feng, Xiaodong Wen, Xudong Xing, and Hua Yang 2025-12-15 18:23:13

[ASAP] Development of a Sensitive Lateral Flow Immunoassay Using Recombinant Rabbit Single-Chain Variable Fragments Fused to a Nitrocellulose-Binding Protein

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04510

— Ngoc Minh Nguyen, Ryosuke Mukai, Makoto Nita, Fuki Yokoyama, Ngoc-Lan Thi Nguyen, Jun-Ichi Horiuchi, and Yoichi Kumada 2025-12-15 17:54:08

[ASAP] In Situ, Time-Resolved Measurements of Lithium-Ion Battery Gases During Cell Formation Using Mid-IR Laser Absorption Spectroscopy

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04714

— Raghav G. Poddar, Joshua Stiborek, Nathan J. Kempema, David Bilby, and Christopher S. Goldenstein 2025-12-15 18:37:39

[ASAP] Portable Sensor for Detecting Trifluoroacetic Acid in Bottled Water: A Visualization Method Based on Multiple Synergistically Induced Aggregation

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04785

— Haocheng Yang, Siyu Huang, Jinhong Luo, Yuting Zhou, Shengshen Gu, and Haifeng Zhou 2025-12-15 16:57:11

[ASAP] Quantum Dots-Enhanced Laser-Induced Breakdown Spectroscopy for Ultrasensitive Quantification of Trace Metals in Oils

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04793

— Wanying Ding, Shilong Xu, Youlong Chen, Congyuan Pan, Jiajie Fang, Shengjie Ma, Xin Wang, Yuhao Xia, and Yihua Hu 2025-12-15 19:09:36

[ASAP] Quantitative Detection of Serum Protein-Specific Glycosylation in Ovarian Cancer Based on a Signal-Convertible Mass-Tagged Probe Set

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05511

— Bo Sun, Yiming Zhao, Yang Li, Danzhuo Liu, Hankun Hu, Hong Cheng, and Liang Liu 2025-12-15 13:24:37

[ASAP] Ionophore-Based SERS Nanosensors for Selective Electrolyte Detection and Intracellular Mapping

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05634

— Laiqi Zhang, Zhiyu Tang, Alejandra Coronel-Zegarra, Vivian Merk, Xingquan Zhu, and Renjie Wang 2025-12-15 20:09:27

[ASAP] Chemigenetic Nanoprobe for Proximity Sensing Dynamics of Lactate Efflux

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05718

— Qin Xu, Xu Zhao, Li-Jian Chen, An-Dong Shao, and Xiu-Ping Yan 2025-12-15 17:29:09

[ASAP] Bimetallic Valence Modulation Strategy Boosted Peroxidase-/Laccase-like Activity of a MoCu-2MI MOF Nanozyme for Portable-Device-Enabled Trimodal Sensing of D-Penicillamine and Colorimetric Analysis of Phenolic Pollutants

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05901

— Daoqing Fan, Shuai Qin, Chuanping Li, Yujia Ren, Lilin Hao, Hengqian Zhang, Jiawen Han, Jingyu Hou, Juan Wang, and Shaojun Dong 2025-12-15 15:26:13

[ASAP] Superhydrophobic MXene Spherical Cavity Arrays as Surface-Enhanced Raman Scattering Sensors for Label-Free Gas Detection and Photothermal Desorption

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c06271

— Guangming Zhang, Yang Wu, Wanning Dou, Mingrui Shao, Chang Ji, Zhiyang Pei, Zhen Li, Jing Yu, Chao Zhang, and Xiaofei Zhao 2025-12-15 10:01:26

[ASAP] A Versatile CRISPR/Cas12a Autocatalytic Cascade System via Structure-Switching V-Type Split Probe for Highly Sensitive DNA Diagnostics

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c06488

— Zhun Lin, Zhe Pu, Jiacheng Wu, Jialin Zeng, Quanhao Dou, Miao Mao, and Yuanqing Zhang 2025-12-15 11:03:19

[ASAP] Utilizing Engineered Monobodies for the Electrochemical Quantification of Lysozyme

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c03304

— Sunanda Dey, Andrew Naser, Daniel R. Woldring, and David P. Hickey 2025-12-14 18:49:40

[ASAP] Multifunctional Composite Coating-Enhanced Flexible Microelectrodes for Chronic, High-Fidelity Neural Signal Recording

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04799

— Ji Pang, Yuyang Sun, Tingting Cheng, Jine Wang, Xuan He, Ying Xiang, Weihao Zhu, Yijia Cao, Meng Wu, Weihua Pei, Renjun Pei, and Yi Cao 2025-12-14 18:50:37

[ASAP] In-Line NMR Diagnostics of Hydroformylation Provided by the Segmented-Flow Microfluidic Regime

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05154

— Mahmoud E. A. Eid, Maria V. Nenasheva, Aleksei N. Bulgakov, Alexander V. Soldatov, Dudari B. Burueva, Elizaveta S. Kononenko, Ivan V. Skovpin, Igor V. Koptyug, Dmitry N. Gorbunov, and Alexander A. Guda 2025-12-14 13:51:11

[ASAP] Electroanalysis Using Isostatic Graphite Electrodes

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04846

— Tasneem Omda Edrees Isaa, Ala’a Mhmoued Abdllh Alboull, Hao Jiang, Ghulam Mustafa, Tsegu Lijalem, Valentin Mirceski, and Guobao Xu 2025-12-13 14:57:33

[ASAP] Visualizing Viscosity Changes in Tumor and Rheumatoid Arthritis with a Dual-Targeted NIR Fluorescent Probe

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05774

— Peng Lei, Pengjia Wei, Chuan Dong, Shaomin Shuang, and Minglu Li 2025-12-13 13:55:47

[ASAP] A Novel Ficoll400-Based Signal Amplification Platform for High-Sensitive Cardiac Troponin I Immunoassay

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c06026

— Chaolin Guo, Meng Liu, Shuaipeng Li, Ludan Xie, Kuiqi Jin, Yang Sun, Jianqi Nie, and Zhonghu Bai 2025-12-13 16:50:57

[ASAP] Source Fingerprinting of PFOA via Full- and Intramolecular Stable Isotope Ratios of Carbon Using Orbitrap-IRMS

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c06168

— Holden M. Nelson, Zhiliang Xu, Hui Li, and James J. Moran 2025-12-13 13:56:16

[ASAP] Proximity-Inducible CRISPR/Cas12a Activity by Scaffold RNA Assembly for Sensing Applications

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c06530

— Yin Gang Nie, Hong-Shuai Zhang, Mei Su, Cheng Jun Zha, Kai Yang, and Zhan Ming Ying 2025-12-13 14:58:38

[ASAP] Time-Resolved “Barbecue” Förster Resonance Energy Transfer for Sensitive and Homogenous Detection of Alginate

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c03101

— Anran Zhang, Xuanwei Mei, Qianqian Lyu, Rui Feng, Jingyue Xu, Jiangkun Yan, Shaoqin Zhai, N. Connor Payne, Yong Wang, Ralph Mazitschek, Yaoguang Chang, and Xue Qiu 2025-12-12 15:16:09

[ASAP] DeepMIR: A Hybrid Convolutional Neural Network-Transformer Framework for Accurate Identification of Target Components from Mid-Infrared Spectra of Mixtures

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04545

— Lin Tan, Yue Wang, Hailiang Zhang, Jinyu Sun, Qiong Yang, Xiao Yang, Zhimin Zhang, and Hongmei Lu 2025-12-12 15:47:03

[ASAP] Recent Progress in Flexible Medical Sensors: Materials, Mechanisms, and Multifunctional Applications

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04956

— Yingqing Yu, Qiushi Wang, Jiandong Cui, Yazhou Yuan, Hao Zhang, Haibo Liu, Yunhong Liang, and Suqian Ma 2025-12-12 13:26:26

[ASAP] Orthogonal Biochemical Sensing for Concentration-Independent Bacterial Fingerprinting

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05097

— Xin Wang, Lilin Yin, Haiyan Li, Huida Li, Ying Cao, Ting Yang, and Jianhua Wang 2025-12-12 20:21:59

[ASAP] Hierarchically Porous Amino-Functionalized Microporous Organic Networks Coated Fiber for Sensitive Breath Metabolite Profiling: A Noninvasive Strategy for Gastric Cancer Diagnosis

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05272

— Pengfei Li, Feiran Zhang, Hong Wang, and Hongyuan Yan 2025-12-12 14:36:02

[ASAP] Three Conformations of Polyglutamic Acid Monitored by Vibrational Optical Activity

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05531

— Andrii S. Kurochka, Jana Hudecová, Josef Kapitán, Jiří Kessler, and Petr Bouř 2025-12-12 17:16:18

[ASAP] Integrated Biomimetic Platform for Enhancing the Efficient Capture and Visual Identification of Circulating Tumor Cells

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c06259

— Tianyu Zeng, Ben Li, Jialin Xu, Yanting Sun, Yunlong Xiao, Zhengxing Zhou, Yijia Hua, Shuai Wu, Hai Shi, Genxi Li, and Yongmei Yin 2025-12-12 09:31:38

[ASAP] Real-Time Monitoring of Drug Release in Whole Blood Based on Optical Interferometry

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c06358

— Nian Ding, Na Ni, Xinyu Yang, Wei Wei, and Qianqian Su 2025-12-12 09:05:57

[ASAP] Calibrated Uncertainty Estimation for Soil Organic Carbon from Raman Spectra

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04616

— Jeffrey K. Wiens, Natalia Solomatova, and Sadegh Shokatian 2025-12-11 15:23:07

[ASAP] Highly Sensitive Molecular Detection Using Tapered Fiber with Ag Nanoparticle Self-Assembled Film for Confined-Enhanced Raman Spectroscopy

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04942

— Xiaohua Yang, Yafei Shi, and Jixiang Fang 2025-12-11 20:16:48

[ASAP] Proteome-Wide Analysis and Surface Protein Isolation for Secretome Characterization Reveal Insights into the Biology of the Leaf-Cutter Ant Acromyrmex echinatior

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05220

— Penghsuan Huang, Joseph Sardina, Haiyan Lu, Gaspar Bruner-Montero, Cameron R. Currie, and Lingjun Li 2025-12-11 12:42:21

[ASAP] Seawater Salinity Measurement Using Laser-Induced Plasma: Acoustic–Spectral Characteristics and Analytical Performances

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05320

— Ye Tian, Qingxi Liu, Beibei Wang, Pingsai Chu, Yuanyuan Xue, Zuohe Shi, Jinjia Guo, Yuan Lu, Wenhua Song, and Ronger Zheng 2025-12-11 12:53:35

[ASAP] Combining Retip Retention Time Prediction with High-Resolution Mass Spectrometry: A Systematic Analysis of Schisandra chinensis-Evodia Conducted for the First Time

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05620

— Jiaqi Xu, Lincheng Bai, Tiantian Wang, Zeyu Yi, Hua Han, and Peiliang Dong 2025-12-11 17:56:57

[ASAP] Combined Use of Engineered PfAGO and LbCas12a for Nucleic Acid Detection

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05622

— Wanting Zeng, Xiaochen Xie, Xiaolan Yu, Ting Zhang, Tianxin Cai, Shi Chen, Wanping Chen, Fei Wang, Longyu Wang, and Lixin Ma 2025-12-11 18:54:09

[ASAP] 3D-Printed Potentiometric Multicells for Enhanced Analytical Performance of Solid Contact Ion-Selective Electrodes

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c06253

— Dario Torricelli, Daniel Rojas, María Cuartero, and Gastón A. Crespo 2025-12-11 12:31:55

[ASAP] Machine Learning-Assisted False Positive Detection in Metabolite Identification Workflows

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c02745

— Ramon Adàlia, Paula Cifuentes, Joyce Liu, Lionel Cheruzel, Gemma Sanjuan, Tomàs Margalef, and Ismael Zamora 2025-12-10 12:33:31

[ASAP] Surface-Enhanced Raman Spectroscopy–Machine Learning for Multiplex Naphthenic Acid Profiling in Water

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04463

— Mohammadamin Rashidi, Zahra Kianpoor, Hongyan Wu, Xiaomeng Wang, Jinfeng Liu, Nobuo Maeda, and Xuehua Zhang 2025-12-10 14:16:35

[ASAP] A Streamlined Sequential Enrichment Strategy for Multi-PTM Profiling from Low Micrograms of Samples

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04541

— Geyi Zheng, Ling Zhao, Mingxiu Liang, Xiuwen Yu, Chuanxi Huang, Fuchu He, and Wendong Chen 2025-12-10 11:06:05

[ASAP] Highly Catalytic FeS2@CoS2 Core/Shell Nanocubes for Ultrasensitive Electrochemical Assay of Microphthalmia-Associated Transcription Factor via Nucleic Acid Signal Amplification Cascades

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04603

— Jianmei Yang, Qianhong Chen, Ruo Yuan, and Yun Xiang 2025-12-10 12:05:02

[ASAP] Precision Strike at Lipid Droplets by Spherical Nano-Browning Agents Promotes Obesity Remission

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04828

— Chen Wei, Xinguo Jin, Ying Zhao, Yu Zhang, Fangling Wang, Hongshuai Wei, Jian-Hua Wang, and Zejun Wang 2025-12-10 12:59:25

[ASAP] Quasi-Simultaneous Detection of Ammonia and Nitrous Oxide by Photoacoustic Phase-Resolved Method: A Proof-of-Concept

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04976

— Daniel da Silva Santos, Leonardo Mota, Guilherme Rodrigues Lima, Eduardo César da Matta, Thiago Lemos Alvarenga, Marc-Simon Bahr, Israel Andrade Esquef, Marcus Wolff, and Marcelo Gomes da Silva 2025-12-10 20:32:20

[ASAP] A Ratiometric Multimode Optical Sensor for Highly Selective and Sensitive Detection of Harmful Heavy Metal Hg2+ in Freshwater and Seawater

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05299

— Xin Qi, Qian Liu, Wanting Zhang, Guorui Gao, Yu Ma, and Bo Tang 2025-12-10 14:13:31

[ASAP] A Deep Learning Model for Efficient Nontargeted Screening of New Psychoactive Substances with Benchtop Nuclear Magnetic Resonance Devices

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c05514

— Pengfei Liu, Wei Jia, Cuimei Liu, Zhendong Hua, Yu Du, Zehua Yu, and Jun Tao 2025-12-10 10:39:18

[ASAP] Hyperbranched Aggregation-Induced Emission Luminogen-Based Sensor Array for Highly Sensitive Discrimination of Multiple Proteins

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c06029

— Shiyu Zang, Xiao Dong, Haozhi Song, Xiaolei Su, Jianbo Ma, Keyan Deng, Rongli Yang, and Shuo Wu 2025-12-10 19:03:33

[ASAP] Analytical Separation of Lithium and Multi-ions from Complex Brines Using Nanointerface Engineered Membranes

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c06754

— Yueyu Liu, Lili Gao, Zhongyu Du, Shiwei Li, Libo Zhang, and Shaohua Yin 2025-12-10 14:36:42

[ASAP] GPMassSimulator: A Graphormer-Based Method for Glycopeptide MS/MS Spectra Prediction

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c02375

— Yihui Ren, Dongbo Bu, Bo Duan, Chunming Zhang, Bin Cong, and Shiwei Sun 2025-12-09 16:01:13

[ASAP] Application and Prospects of Large Language Models in Small-Molecule Drug Discovery

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04083

— Jin Ma, Jia Liu, Dongyu Xu, Xiaoyu Song, and Zhichang Zhang 2025-12-09 17:04:36

[ASAP] HDSE-MS: Tandem Mass Spectrum Prediction for Small Molecules via Hierarchical Distance Structural Encoding

Analytical Chemistry

DOI: 10.1021/acs.analchem.5c04111

— Zhangqiang Liu, Bingyi Wang, Congcong Yang, Nannan Bai, and Weihua Li 2025-12-09 18:32:56