Charge site derivatization

IUPAC RECOMMENDATIONS 2013
Charge site derivatization
Chemical derivatization of molecules to introduce a fixed charge site, thus improving ionization efficiency by electrospray ionization or matrix-assisted laser desorption/ionization and directing subsequent ion fragmentation in a manner that facilitates structure identification. Note: Examples are quaternary ammonium or phosphonium derivatization.
Related Term(s):
Reference(s): X. Czeszak, W. Morelle, G. Ricart, D. Tetaert, J. Lemoine. Anal. Chem. 76, 4320 (2004). (http://dx.doi.org/10.1021/ac049767q )
From Definitions of Terms Relating to Mass Spectrometry (IUPAC Recommendations 2013); DOI: 10.1351/PAC-REC-06-04-06 © IUPAC 2013.
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