Protein footprinting

DRAFT DEFINITION
Protein footprinting
Method for protein structure determination using oxidative modification of amino acid side chains in the presence of H218O with subsequent analysis by mass spectrometry.
Related Term(s): Hydrogen/deuterium exchange, Peptide mass fingerprinting, Stable isotope labeling
Reference(s): S. D. Malekni, M Brenowitz, and M. R. Chance, Millisecond Radiolytic Modification of Peptides by Synchrotron X-rays Identified by Mass Spectrometry, Anal. Chem. 1999 71, 3965-3973, http://dx.doi.org/10.1021/ac990500e
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