RSS:Analyst

From Mass Spec Terms

Analyst

RSS

RSS Feed

Recent Advances in MXene Nanozymes: Synthesis, Surface Modifications, Catalytic Properties, and Their Emerging Roles in Biosensing and Therapeutic Applications
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01137J, Tutorial Review
Hatem A. Al-Aoh, Chellasamy Panneerselvam, Asim M Alghamdi, Abdulrahman Alasmari, Zuhair M Mohammedsaleh
The present review highlights recent advancements and future prospects in the development and application of MXene-based nanozymes, emphasizing their potential in biosensing, therapeutics, and theranostics. Eco-friendly and scalable synthesis methods,...
The content of this RSS Feed (c) The Royal Society of Chemistry
Surface charge engineering enhances symmetry and reliability of nanopores formed via dielectric breakdown

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00882D, Paper
Guohao Xi, Gang Hu, Jie Ma, Lingzhi Wu, Jing Tu
Variations in the electrical properties of modified layers induce distinct changes in electron cloud distribution.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
A valence-state-defect–mediated copper nanocluster nanozyme with high peroxidase-like activity for multimodal colorimetric detection of mercury(II)

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01159K, Communication
Zhong-Xia Wang, Peng Shan, Ze-Yu Sun, Weijie Ding, Fen-Ying Kong, Heng-Ye Li, Wei Wang
CuNC-based nanozyme multimodal colorimetric mercury(II) sensing is reported for the first time, demonstrating portability, manipulation, and rapid, selective and sensitive signal response.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Liquid-Liquid Phase Separation-Assisted Raman Microscopy for Sensitive and Label-Free Analysis of Enzymatic Reactions and Protein-Small Molecule Interactions
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00973A, Paper
Lisa Kageyama, Shinya Tahara, Reona Tobita, Shinji Kajimoto, Takakazu Nakabayashi
Raman spectroscopy enables label-free and non-destructive structural analysis of biomolecules; however, its application is limited by the inherently weak Raman signals, which necessitate high concentrations of biomolecules for detection. In...
The content of this RSS Feed (c) The Royal Society of Chemistry
Elucidating time-resolved intracellular metabolic dynamics via label-free Raman microspectroscopy and 2D correlation spectroscopy

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01114K, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zohreh Mirveis, Nitin Patil, Hugh J. Byrne
Understanding dynamic metabolic processes is central to elucidating cellular function and disease mechanisms.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
DNAzyme walker-driven, electrode-surface label/wash-free ultrasensitive ECL miRNA detection via ssDNA-enhanced peroxidase activity of g-C3N4 nanosheets

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01164G, Paper
Jingwen Wu, Changgang Pan, Li Wang, Yuefeng Li, Guo-Xi Liang
A DNAzyme walker-driven, label/wash-free ECL biosensor for miRNA detection. The cleavage of substrate strands by the target miRNA releases ssDNA, which dramatically enhances the peroxidase-like activity of g-C3N4, leading to high sensitivity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal So...
Anti-tumour and associated metabolic effects of repurposed afuresertib and taxifolin for glioblastoma treatment

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00461F, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rui Chen, Nurcan Gumus, Supisara Jearranaiprepame, Alison Whitby, Ruman Rahman, Dong-Hyun Kim
Treating patient-derived glioblastoma cells with repurposed afuresertib and taxifolin showed strong anti-tumour activities and distinctive metabolic disturbance. Created with BioRender.com.
To cite this article before page numbers are assigned...
On-chip filtration enrichment and ultrasensitive nanozyme-catalyzed colorimetric detection of Streptococcus pneumoniae in saliva samples
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00879D, Paper
Yuancheng Guo, Zhijie Tu, Hong Chen, Hongjuan Wei, Tianci Wang, Guohui Sun, Zhen Rong
Streptococcus pneumoniae (S. pneumoniae) is a major cause of respiratory infections, requiring rapid, sensitive, and accessible diagnostic tools for early intervention, especially in resource-limited settings. Herein, we developed a microfluidic...
The content of this RSS Feed (c) The Royal Society of Chemistry
From Design to Application: Developments and Challenges of Nanomaterial-Based Optical Biosensors for Salmonella Detection
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00910C, Tutorial Review
Bin Wang, Yuan Tian, Zerun Zhang, Tianhan Kai, Jun Xiang, Pian Wu, Ping Ding
Salmonella is a widely distributed foodborne pathogen that poses a serious threat to public health.Traditional detection methods suffer from limitations such as being time-consuming, complex, and reliant on expensive equipment,...
The content of this RSS Feed (c) The Royal Society of Chemistry
Correction: Highly-selective and sensitive plasmon-enhanced fluorescence sensor of aflatoxins
Analyst, 2025, Advance Article
DOI: 10.1039/D5AN90087E, Correction
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Tetyana Sergeyeva, Daria Yarynka, Vitaly Lytvyn, Petro Demydov, Andriy Lopatynskyi, Yevgeny Stepanenko, Oleksandr Brovko, Anatoliy Pinchuk, Volodymyr Chegel
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
A near-infrared benzothiazole-based fluorescent probe for selective detection of CORM-3 with large Stokes shift in living cells
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01196E, Paper
Liqiang Yan, Junjie Yang, Yanxin Zhang, Ying Sun, Jianmei Zou
Carbon monoxide (CO) is a key signaling molecule in mammals, playing essential roles in cell protection, maintenance of cellular homeostasis, and exhibiting great therapeutic potential for various diseases. Moreover, dysregulation...
The content of this RSS Feed (c) The Royal Society of Chemistry
Advances in gene-targeted diagnostics for pathogenic Escherichia coli

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00836K, Tutorial Review
Linlin Zhuang, Jiansen Gong, Mengling Zhu, Ying Zhao, Xue Lian, Chuang Zhou, Xia Cao, Yu Zhang, Qiuping Shen
This review provides a comprehensive overview of gene-targeted diagnostics for pathogenic Escherichia coli, covering nucleic acid hybridization, PCR-based methods, isothermal amplification, biosensors, sequencing technologies, and emerging assays.
To cite this article before page numbers are assigned, use the DOI form ...
Correction: High-sensitivity SpectroChip-integrated LFIA platform for rapid point-of-care quantification of cardiovascular biomarkers
Analyst, 2026, Advance Article
DOI: 10.1039/D5AN90088C, Correction
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Cheng-Hao Ko, Wei-Yi Kong
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Portable smartphone assisted multi-color colorimetric sensor for the detection of mercury ions based on the peroxidase-like activity of platinum nanoparticles
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01167A, Paper
Shasha Wang, Huiqing Zhang, Li Wang, Chaonan Huang, Jiping Ma, Liyan Wang, Xiaoyan Wang, Lingxin Chen
An innovative multi-color colorimetric method integrated with smartphone detection was designed with great sensitivity and specificity for determination of mercury ions (Hg2+) in aqueous samples based on platinum nanoparticles (PtNPs)...
The content of this RSS Feed (c) The Royal Society of Chemistry
Advances and innovations in machine learning-based spectral detection methods for trace organic pollutants
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00903K, Tutorial Review
yiheng qin, Qiannan Duan, Haoyu Wang, yonghui bai, yihao qin, Liulu Yao, Fan Song, Mingzhe Wu, Jianchao Lee
The rapid and sensitive detection of trace organic pollutants in water is crucial for ensuring environmental safety. Traditional detection methods struggle to meet the demands of large-scale, real-time, and on-site...
The content of this RSS Feed (c) The Royal Society of Chemistry
Flexible hydrogel sensor based on MoS2 for highly selective dopamine detection against catecholamine cross-interference

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01080B, Paper
Jianyu Liu, Xiaolei Gao, Weifang Ma, Liyuan Zhang, Xiaoming Wen, Ming Zhai, Guobi Chai, Wu Fan, Qidong Zhang, Ronghan Wei, Qiyan Wang
Real-time monitoring of dopamine (DA) is vital for understanding neurophysiological processes and diagnosing neurological disorders.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Chemical additives facilitate molecular weight characterization of underivatized dextran by high-resolution electrospray ionization mass spectrometry

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01066G, Paper
Yujia Ying, Jiangang Chen, Shaoping Li, Jing Zhao
Ionization is usually difficult for underivatized dextran. After adding chemical additives, large polysaccharide ions can be investigated and their fragments are highly related with the structures.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Design and synthesis of fluorescent probes specific for pantetheinase and their application in bioimaging

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00338E, Paper
Jiman He, Zhengmin Yang, Cunji Gao, Zhiwei Ouyang, Bingying Cao, Yaling Rao, Liangliang Xiao, Shulin Zhao, Jiangke Qin
The FNJ-PA probe interacts with Vanin-1, it can specifically recognize and cleave the amide bond of the probe, releasing the fluorophore FNJN to recover the fluorescence.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemi...
A label-free approach to simultaneous determination of three endocrine disruptors in river water: angular sweep total fluorescence spectroscopy coupled to multi-way calibration

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00925A, Paper
Anupama Vijayan, John Prakash
Three endocrine disruptors, BPA, CBZ and CBR, are detected in river water using a sustainable workflow combining single-step surfactant pretreatment, angular sweep fluorescence spectroscopy, and PLS-based modelling.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Pocket-sized lab: rapid screening of Fe(III), Na(I), and pyridoxamine via a smartphone-enabled fluorescent PAD

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00968E, Paper
Heni Soni, Krushna Baraiya, Divyesh Chaudhari, Sahaj A. Gandhi, Pinkesh G. Sutariya
A smartphone-assisted fluorescent paper-based analytical device (PAD) for the on-site detection of Fe(III), Na(I), and pyridoxamine vitamin.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Precise Klebsiella pneumoniae carbapenem resistance prediction by Zn–Cu/MOF-embedded hybrid nanosheet-assisted carbapenemase activity analysis

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00967G, Paper
Chenyao Lin, Qiaoping Wu, Menglu Mao, Xuedan Qiu, Chuanfan Ding, Yinghua Yan, Dumei Ma, Qingcao Li
A novel GNP@Zn–Cu/MOF@Au nanocomposite enables rapid and sensitive detection of carbapenemase activity by MALDI-TOF MS, offering a promising tool for clinical antimicrobial resistance testing.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of C...
Liposome array on a power-free microfluidic device for analysis of nanopore formation

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01113B, Paper
Maho Hosokawa, Yiting Zhang, Masaki Ohtawa, Naoki Sasaki
A power-free microchannel-based platform that can accommodate numerous liposomes enables real-time analysis of Amphotericin B-induced nanopore formation, providing a high-throughput tool for screening enhancers and inhibitors of drug activity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Socie...
Detection of 2,4-Dichlorophenoxyacetic acid by smartphone- based fluorescence detection coupled with ImageJ analysis on a molecularly imprinted membrane/ carbon dots via Schiff-based method
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00842E, Paper
Muhammad Sajjad, Wijitar Dungchai, Nisakorn Thongkon
The persistent presence of 2,4-dichlorophenoxyacetic acid (2,4-D) in aquatic ecosystems poses a significant risk to both environment and human health. This study presented a novel fluorescence-based sensor designed to detect...
The content of this RSS Feed (c) The Royal Society of Chemistry
Vibrational spectroscopy combined with chemometric approaches in bacterial studies: a review of recent advances and applications

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00802F, Tutorial Review
Maryam Kazemi, Arash Mahboubi, Reza Jahani, Hamid Reza Moghimi
Vibrational spectroscopy combined with chemometrics is expected to provide a high-throughput and a more efficient analytical approach for handling bacterial infections as one of the leading causes of global mortality and public health challenges.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed ...
Identification of organochlorides in distilled fractions of plastic pyrolysis oil using GC × GC coupled with high-resolution time-of-flight mass spectrometry (GC × GC-HR-TOFMS) and GC coupled with a halogen selective detector (GC-XSD)

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00852B, Paper
Bruno da Costa Magalhães, Pascal Pijcke, Niels Verhoosel, Philip Janssen, Cesare Benedetti, Matthijs Ruitenbeek, Georgios Bellos, Melissa N. Dunkle
A crude plastic pyrolysis oil was distilled into fractions with intervals of 50 °C. By combining different analytical capabilities, several organochlorides were speciated across the distilled fractions.
To cite this article before page numbers are assigned, use the DOI form of citation ab...
Single-molecule nanopore profiling of protein domain fragment dynamics and aggregation

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01140J, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Dapeng Chen, Fei Zheng, Guangle Qin, Chaofan Ma, Wei Liu, Lichun Zou, Haiyan Wang, Jingjie Sha
Single-molecule nanopore profiling reveals voltage- and environment-dependent conformational dynamics, dimerization, and dissociation of SARS-CoV-2 nucleocapsid protein domain fragments, advancing nanopore-based protein domain analysis for a...
Protection-free fabrication of glycopolymer-decorated electrodes for label-free electrochemical detection of pathogenic bacteria

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01136A, Communication
Lucen Li, Qinhan Chen, Aobin Han, Qiaolin Guo, Minghui Wang, Wei Song, Jing Lin, Gefei Li
A protection-free interfacial glycosylation strategy was developed to fabricate glycopolymer-modified electrodes, enabling label-free detection of pathogenic bacteria down to 102 CFU mL−1 in real food samples.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Ro...
A fast-responding dual-mode probe for colorimetric and turn-on fluorescence sensing of mercury(II) in water and living cells

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00908A, Communication
Yanxin Wu, Huiyuan Wang, Kai Wei, Chendong Ji, Meizhen Yin
A mercury-sensitive probe (Cy-M) exhibits high sensitivity, excellent selectivity, and low detection limits with rapid response times. Its dual-mode sensing enables naked-eye detection of Hg2+ and live-cell imaging via turn-on fluorescence.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Roya...
Hydrazine oxidation on a single electrocatalytic nanoring

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00651A, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sakshi A. Ailawar, Guillermo Colón-Quintana, Thomas B. Clarke, Jeffrey E. Dick
The schematic illustrates the electrocatalytic oxidation of hydrazine (N2H4) on a gold nanoring electrode deposited on a kinetically inert planar electrode.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The conten...
Integrated microfluidic platform for programmable multi-window DNA fractionation and in situ recovery

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01091H, Paper
Dongliang Li, Chunlei Yang, Leiyang Xu, Tao Zeng, Xiao Shi, Quanxin Yun, Yuliang Dong, Yuning Zhang
An on-chip MFIGE platform integrating programmable DNA size selection with in situ dual-membrane recovery, enabling multi-window, high-fidelity enrichment of long fragments in a closed, low-shear, automation-ready format for long-read sequencing.
To cite this article before page numbers are assigned, use the DOI form of citation above.
Th...
A fluorescence biosensor based on a cell-free transcription system for species-specific DNA sequence detection and seahorse product identification

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01099C, Paper
Linyue Tang, Qian Xie, Ming Chen, Cuiying Lin, Fang Luo, Zhongqin Li, Zhenyu Lin
A fluorescent biosensor based on a cell-free RNA transcription system was developed for species-specific DNA sequence detection and seahorse product identification.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
A reagent-centred thermal control system driven by a cascade temperature control algorithm for high-speed PCR

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00965K, Paper
Yuheng Luo, Wangyang Hu, Jiajia Wu, Baoce Sun, Gang Jin, Qiang Xu
Accelerating quantitative polymerase chain reaction (qPCR) without compromising analytical fidelity remains a significant challenge in molecular diagnostics, primarily due to the thermal lag between heating elements and reagents.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of...
Development of liquid biopsy for screening colorectal cancer through the combination of an antibody microarray-based metal-enhanced sandwich immunofluorescent assay of cytokines with machine learning

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01041A, Paper
Wanyu Zhang, Shasha Li, Xudong Sun, Zhenxin Wang
The simultaneous determination of the expression levels of multiple inflammation-associated cytokines in blood holds great promise for the early screening of cancer including colorectal cancer (CRC).
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
A practical guide to working with nanopipettes

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01128K, Tutorial Review
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Dominik Duleba, Adria Martínez-Aviñó, Robert P. Johnson
This perspective provides a practical guide to nanopipette fabrication, filling, surface modification, and characterisation. Various tips are given to facilitate more efficient workflows and increase research quality and throughput.
To cite this article before page nu...
Computational and design of experiment strategies to improve differentiation and quantitation of trace-level cannabinoids by copper cationization paper spray mass spectrometry

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01073J, Paper
Open Access Open Access
Jindar N. S. Sboto, Chris G. Gill
Copper cationization with paper spray mass spectrometry is sensitive and specific for quantifying cannabinoids. Design of experiment and density functional theory provided optimal metal ion candidates and paper substrate preparation conditions.
To cite this article before page numbers are...
Dramatically enhancing electrochemiluminescence performance in the aqueous phase using naphthalene diimides with excellent electron-transfer capability and water solubility

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01074H, Paper
Dalong Xu, Yuqi Wang, Mingxiu Tian, Liuxiang Chen, Zhengang Han
Luminescent substances with superior electron transfer capability and excellent water solubility are ideal candidates for constructing high-performance electrochemiluminescence (ECL) sensors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Electrochemical determination of copper in seawater based on a patch-type integrated electrode modified with gold nanoparticle-decorated carbon nanoflowers

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01083G, Paper
Shengjie Chu, Fei Pan, Yuxuan Zhang, Haitao Han, Dawei Pan, Xueping Hu
A patch-type integrated electrochemical sensor based on carbon nanoflowers/gold nanoparticles for determination of copper in seawater.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Advanced multimodal imaging: FLIM, PLIM, and FluoRaman enabled by novel diarylacetylene probes
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00953G, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Joshua G Hughes, Dimitrios Tsikritsis, Alexandra Elizabeth Bailie, Camilla Dondi, Eva Dias, Helen Fielding, Natalie Belsey, Michael Shaw, Stanley W Botchway, Carrie A Ambler, John M Girkin, David R Chisholm
In drug design, understanding the subcellular localisation and physicochemical behaviour of candidate molecules is essential...
Progress of lateral flow assays for the detection of molecular and microbial species: From basic formats to microfluids, CRISPR and artificial intelligence
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN00392J, Tutorial Review
Jamila Husain Kagdi, Vaibhavkumar Nandkishor Mehta, Sanjay Jha, Tae Jung Park, Hirakendu Basu, Suresh Kumar Kailasa
Lateral flow assays (LFAs) have garnered much interest in the biomedical and agricultural sciences because of their user-friendly design, quick turnaround times, minimal interference, affordability, and ease of use by...
The content of this RSS Feed (c) The Royal Society of Chemistry
Correction: Utilizing quantum fingerprints in plant cells to evaluate plant productivity
Analyst, 2025, 150,5568-5568
DOI: 10.1039/D5AN90080H, Correction
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Umadini Ranasinghe, Abigail L. Stressinger, Guangpeng Xu, Yasmin Sarhan, Fred Harrington, James O. Berry, Tim Thomay
The content of this RSS Feed (c) The Royal Society of Chemistry
Determination of veliparib metabolic stability in the human liver microsomes using a hydrophilic interaction UPLC-MS/MS quantitative method: greenness assessment with an in silico study for ADME, DEREK alarms and metabolic lability

Analyst, 2025, 150,5501-5513
DOI: 10.1039/D5AN01132A, Paper
Mohamed W. Attwa, Ali S. Abdelhameed, Haitham AlRabiah, Adnan A. Kadi
Veliparib exhibited a relatively slow extraction ratio, with a low Clint of 22.23 mL min−1 kg−1 and a long t1/2 of 36.48 min. Minor replacements within the pyrrolidine ring (96%) in veliparib may increase the metabolic stability and safety profile.
The content of this RSS Feed (c) The Royal Society of Chemistry
Development of one-step magnetic assay for the detection of fentanyl

Analyst, 2025, 150,5411-5416
DOI: 10.1039/D5AN00361J, Paper
Open Access Open Access
Fabiana Grillo, Elena Piletska, Ewa Moczko, César Cáceres, Sergey Piletsky
A one-step magnetic fluorescence immunoassay enables sensitive and specific fentanyl detection in blood plasma with minimal handling and no cross-reactivity to related opioids.
The content of this RSS Feed (c) The Royal Society of Chemistry
Octahedral Ce-MOF as an electrochemical sensor for the detection of chloramphenicol

Analyst, 2025, 150,5531-5537
DOI: 10.1039/D5AN01008J, Paper
Yuting Luo, Yiwei Sun, Haoxiang Wang, Yuyang He, Ruoyu Wang, Mengqi Lu, Yingong Wang, Xinlong Yan, Dongpo Xu
The electrochemical performance of Ce-MOF@Apta was evaluated by cyclic voltammetry and differential pulse voltammetry. Ce-MOF@Apta has a wide detection range (1 nM–10 mM), low detection limit, good selectivity, stability and reproducibility.
The content of this RSS Feed (c) The Royal Society of Chemistry
A sustainable and novel LC-TQ-MS/MS method for quantifying mutagenic Ketoconazole-NDSRIs aligned with green and white analytical chemistry principles

Analyst, 2025, 150,5457-5472
DOI: 10.1039/D5AN01052G, Paper
Open Access Open Access
Srinivas Nakka, Vishnu Murthy Marisetti, Surendra Babu Manabolu Surya
Schematic work flow of Ketoconazole NDSRIs determination using LC-TQ-MS/MS.
The content of this RSS Feed (c) The Royal Society of Chemistry
Spatial distribution of differential metabolites in different parts of Curcuma phaeocaulis Val. using ultra-high-performance liquid chromatography-quadrupole Orbitrap high-resolution mass spectrometry and desorption electrospray ionization mass spectrometry imaging

Analyst, 2025, 150,5538-5557
DOI: 10.1039/D5AN01077B, Paper
Ying Zhu, Chuyue Wu, Qinwan Huang, Jin Wang
Roots and rhizomes of Curcuma phaeocaulis Val. are used as distinct traditional Chinese medicines with a reported blood-circulating and stasis-removing effect.
The content of this RSS Feed (c) The Royal Society of Chemistry
An enzyme-free fluorescence biosensor for UO22+ detection using a four-leaf clover-shaped quadruple walker as a signal amplifier

Analyst, 2025, 150,5525-5530
DOI: 10.1039/D5AN00920K, Paper
Nan Hu, Yimei Guo, Ying Zeng, Weichao Zhao, Dexin Ding, Jiafeng Pan, Junhua Chen
Based on four-leaf clover-shaped quadruple walking, an enzyme-free fluorescence biosensor was designed for ultrasensitive detection of UO22+.
The content of this RSS Feed (c) The Royal Society of Chemistry
Toward minimally invasive metabolomics: GC-MS metabolic fingerprints of dried blood microsamples in comparison to plasma

Analyst, 2025, 150,5445-5456
DOI: 10.1039/D5AN00937E, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Daniel Marques de Sá e Silva, Marlene Thaitumu, Christina Virgiliou, Alexandra Tiganouria, Fernanda Rey-Stolle, Glykeria Avgerinou, Anatoli Petridou, Vasileios Mougios, Georgios Theodoridis, Helen Gika
The first comprehensive study comparing global metabolic profiles from three BµS devices against plasma and venous liquid blood using ...
Research progress of technology for exocytosis detection in the nervous system

Analyst, 2025, 150,5379-5393
DOI: 10.1039/D5AN00934K, Minireview
Fu-Li Zhang, Cheng-Bao Xu, Xiao-Ying Zhao, Shi-Yue Du, Jun-Ming Tang
We summarized the progress and application scenarios of common exocytosis detection methods, including brain microdialysis, novel imaging technology, fluorescent probes, and electroanalytical and electrophysiological methods.
The content of this RSS Feed (c) The Royal Society of Chemistry
Enhanced protein synthesis from immobilized circular DNA via triple-helix formation

Analyst, 2025, 150,5403-5410
DOI: 10.1039/D5AN00995B, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Shunsuke Takahashi, Kazuki Hayashi, Jun Okada, Hibiki Takashima, Koko Nakata, Masahiko Oshige, Shinji Katsura
Circular DNA immobilization via triplex formation onto streptavidin surfaces creates orientation-controlled templates. These templates yield approximately 4.6 times more protein than linear DNA in cell-free synthesis and can be ...
V-Ti3C2 nanozyme with peroxidase-like activity for dye removal and the colorimetric detection of Fe3+

Analyst, 2025, 150,5514-5524
DOI: 10.1039/D5AN01014D, Paper
Feng Yang, Congying Ding, Zihui Chen, Guoqing Zhao, Lamei Zhou, Wanqing Yue
Preparation of V-Ti3C2 and its application in dye adsorption and degradation, as well as Fe3+ detection.
The content of this RSS Feed (c) The Royal Society of Chemistry
Nondestructive multiparameter quantification of nanoporous films by broadband SPR/PWR spectroscopy

Analyst, 2025, 150,5432-5444
DOI: 10.1039/D5AN00951K, Paper
Ziwei Liu, Xiumei Wan, Hongyi Tang, Zhi-mei Qi
Nondestructive measurement of film thickness (d) and porosity (P) is crucial for the rational design, controllable synthesis and accurate characterization of multifunctional nanoporous thin films (NPTFs).
The content of this RSS Feed (c) The Royal Society of Chemistry
Differentiation of different subtypes of polystyrene microplastics using Nile red

Analyst, 2025, 150,5424-5431
DOI: 10.1039/D5AN00710K, Paper
Xiaoyan Hu, Chenfei Duan, Qiaocheng Feng, Heng Lu, Liangqia Guo
Five common subtypes of PS MPs were successfully differentiated via fluorescence imaging by controlling NR dyeing conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry
Synergistic coordination-driven ratiometric fluorescence detection of the anthrax biomarker dipicolinic acid

Analyst, 2025, 150,5417-5423
DOI: 10.1039/D5AN00924C, Paper
Junrong Wu, Qian Zhang, Xiaofeng Zhou, Jiaojiao Zhang, Liangquan Sheng, Huajie Xu, Fuying Hao, Zhaodi Liu
A novel ratiometric fluorescent nanoprobe was developed for the detection of the anthrax biomarker dipicolinic acid (DPA) in complex environments and on actual spores, based on the synergistic coordination of a terpyridine derivative and ZIF-8.
The content of this RSS Feed (c) The Royal Society of Chemistry
An automated illumination system for high-throughput photopharmacology studies: a case study of ROS-sensitive Zn- and Pd-phthalocyanine-loaded liposomes

Analyst, 2025, 150,5473-5480
DOI: 10.1039/D5AN00927H, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ali Eftekhari, Olga Lem, Alexander Efimov, Timo Laaksonen, Nikita Durandin
An automated illumination system for high-throughput photopharmacology studies has been developed and validated.
The content of this RSS Feed (c) The Royal Society of Chemistry
Barium ion sensing with IPG K+ molecular probes

Analyst, 2025, 150,5558-5567
DOI: 10.1039/D5AN00577A, Paper
R. L. Miller, N. Byrnes, C. G. Cameron, A. J. Carlson, E. Dey, R. Madigan, J. Medina, S. Melancon, K. E. Navarro, F. W. Foss, B. J. P. Jones, C. Adams, H. Almazán, V. Alvarez, A. I. Aranburu, L. Arazi, I. J. Arnquist, F. Auria-Luna, S. Ayet, C. D. R. Azevedo, K. Bailey, F. Ballester, J. E. Barcelon, M. del Barrio-Torregrosa, A. Bayo, J. M. Benlloch-Rodriguez, F. I. G. M. Borges, A. Brodolin, A. Castillo, E. Church, L. Cid, C. A. N. Co...
Utilizing quantum fingerprints in plant cells to evaluate plant productivity

Analyst, 2025, 150,5394-5402
DOI: 10.1039/D5AN00326A, Paper
Open Access Open Access
Umadini Ranasinghe, Abigail L. Stressinger, Guangpeng Xu, Yasmin Sarhan, Fred Harrington, James O. Berry, Tim Thomay
A quantum fingerprint depicting photosynthetic productivity is developed from quantum light emitters, overcoming the limitations of plant autofluorescence.
The content of this RSS Feed (c) The Royal Society o...
Differentiation of cisplatin uptake within a population of cancer cells – how to “crack this nut” using single-cell ICP-MS

Analyst, 2025, 150,5374-5378
DOI: 10.1039/D5AN00152H, Communication
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zuzanna Szymańska, Magdalena Matczuk, Agnieszka Żuchowska, Paweł Romańczuk, Andrei R. Timerbaev, Maciej Jarosz
A tool to unravel the uptake diversity of cisplatin within a cancer cell population, based on SC-ICP-MS/MS and advanced data processing.
The content of this RSS Feed (c) The Royal Society of Chemistry
AQbD-based headspace GC-MS/MS method development under ICH Q14 guidelines for simultaneous analysis of residual solvents in pharmaceuticals

Analyst, 2025, 150,5481-5500
DOI: 10.1039/D5AN00653H, Paper
Bontha Koteswaramma, Shubham Dhiman, Kalva Bhadrayya, Anupam Jana, Ramalingam Peraman
A risk assessment-driven Analytical Quality by Design (AQbD) approach was applied to develop and validate a headspace GC-MS/MS method for simultaneous quantification of residual solvent impurities (RSIs) in pharmaceutical drug substances.
The content of this RSS Feed (c) The Royal Society of Chemistry
H2O2-free colorimetric sensing platform of Mn-doped carbon dots with oxidase-mimetic activity for the detection of glutathione in liver disease serum

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00964B, Paper
Lin Bo, Lili Jiang, Zhaogui Deng, Minmin Xu, Yifei Liu, Hui Zhang, Xianwei Zuo, Haitao Yu
Schematic of the functional principle of the colorimetric detection of GSH with the oxidase-like mimetic activity of Mn-CDs.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Correction: Synchrotron-based infrared microspectroscopy unveils the biomolecular response of healthy and tumour cell lines to neon minibeam radiation therapy
Analyst, 2026, Advance Article
DOI: 10.1039/D5AN90081F, Correction
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
R. González-Vegas, O. Seksek, A. Bertho, J. Bergs, R. Hirayama, T. Inaniwa, N. Matsufuji, T. Shimokawa, Y. Prezado, I. Yousef, I. Martínez-Rovira
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Ionic Liquid-based Dual-Mode Nano-optode for Ultra-Sensitive Detection of Perchlorate Ions
Analyst, 2026, Accepted Manuscript
DOI: 10.1039/D5AN01064K, Paper
Subekchha Pradhan, Upika Darnal, Shraddha Rai, Subham Lama, Ashish Rai, Rifath Darjee, Najmin Tohora, Sabbir Ahamed, Sudhir Kumar Das
We introduced an orange light-emitting ionic liquid (IL), XBIL, and its dual-mode nano-optode, nXBIL, for selective detection of perchlorate(ClO₄⁻) ions. Comprehensive spectroscopic and microscopic analyses confirmed the structural integrity and...
The content of this RSS Feed (c) The Royal Soc...
Characterizing DPPM inhibition of butyrylcholinesterase: integrated enzymatic kinetics and Raman spectroscopy with chemometric analysis

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01018G, Paper
Aubrey Barney, Ashley Newland, Abraham Olayeri, Jan Halámek, Lenka Halámková
Butyrylcholinesterase (BChE) may serve as a scavenger enzyme protecting against various toxic compounds, but we still don't fully understand how it interacts with fentanyl analogues.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Sensitive detection and accurate bioimaging of circRNA based on sponge amplification using a DNA tetrahedral nanoprobe

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00611B, Paper
Gege Xie, Shengrong Yu, Rong Feng, Jingwen Chen, Yiming Wang, Haorong Liu, Yong-Xiang Wu, Shengjia Yu, Keqi Tang
Based on the miRNA sponge amplification property of circRNA, a novel fluorescent DNA tetrahedron nanoprobe (DTNP) was developed for highly sensitive detection and in situ bioimaging of circRNA in living cells.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Fe...
Boosting living Bacillus spore identification: Kolmogorov–Arnold network-guided convolutional neural network combined with laser tweezers Raman spectroscopy

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00834D, Paper
Yifan Sun, Xiao Peng, Fusheng Du, Lin He, Yuan Lu, Yufeng Yuan, Junle Qu
As primary carriers of foodborne and zoonotic diseases, Bacillus spores can pose a serious threat to food microbiology and human disease.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Metabolic fingerprinting of periodontal bacteria: a multi-scale mass spectrometry and vibrational spectroscopy approach

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00507H, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jawaher Albahri, Daniel Smaje, Yun Xu, Steven Robinson, Heather Allison, Kathryn A. Whitehead, Howbeer Muhamadali
Periodontitis is a prevalent condition characterised by progressive destruction of the supporting periodontium around teeth, resulting from prolonged interaction between the host immune system and bacterial infection.
To ci...
Microanalysis of a single droplet produced by optical tweezers in an aqueous solution of bovine serum albumin

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01045D, Paper
Ayana Takayanagi, Yasuyuki Tsuboi, Ken-ichi Yuyama
We apply optical tweezers to form a single protein-rich microdroplet in a BSA–YCl3 solution, enabling precise in situ microscopic and microspectroscopic analyses through high spatial and temporal control of liquid–liquid phase separation.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of C...
Transition metal doping boosting paper-based photoelectrochemical immunosensing for neurofilament light chain protein detection

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01030F, Paper
Cheng-Hua Xu, An-Yang Tao, Mei-Qing Meng, Xi-Le Zhang, Cheng Fang, Feng-Zao Chen, De-Man Han
Early diagnosis of neurodegenerative diseases relies on highly sensitive detection of their specific biomarkers.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
A DNAzyme amplifier-based immunoassay for small molecule detection

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN01013F, Paper
Open Access Open Access
Han Pang, Qiang Zhao
A DNAzyme amplifier-based immunoassay for sensitive detection of small molecules is developed by using DNAzyme labeled small molecules and antibodies coated on microplates.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Ro...
SpectralFlow: an integrated platform for spectral data preprocessing and predictive modeling analysis in fruit quality evaluation

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00794A, Paper
Zhikai Chen, Guanzhi Lyu, Xiaochan Wang, Mengfei Yang, Xin Xu, Xiaolei Zhang
An overview of SpectralFlow's features and two specific case demonstrations are presented.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Recent advances in fluorescence-colorimetric sensor arrays and their applications in biomedical fields

Analyst, 2026, Advance Article
DOI: 10.1039/D5AN00900F, Tutorial Review
Liuwen Shao, Jiannan Liu, Xinxin Chen, Wenxiang Xiao
Fluorescence colorimetric dual-mode sensor arrays have drawn significant attention in biomedical analysis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Development and validation of a quick and sensitive UPLC-MS/MS method for measuring ensartinib in HLMs: investigation of structural alerts associated with metabolic lability and in silico toxicity

Analyst, 2025, 150,5174-5189
DOI: 10.1039/D5AN01036E, Paper
Mohamed W. Attwa, Ali S. Abdelhameed, Awadh M. Ali, Haitham AlRabiah, Adnan A. Kadi
According to evaluations performed using the DEREK and WhichP450 modules, slight changes or substitutions in the piperazine ring during drug development could yield new derivatives with improved safety and metabolic stability compared to EST.
The content of this RSS Feed (c) The Royal Society of Chemistry
Cup of Carbon: smartphone-based analysis of dissolved organic carbon in water for use in citizen science

Analyst, 2025, 150,5338-5350
DOI: 10.1039/D5AN00738K, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Michael R. Muir, Adrian M. Bass, Kenny Galt, Kerry Morrison, Lewis Robertson, Emily Taylor
The “Cup of Carbon” method can be used to estimate the concentration of Dissolved Organic Carbon (DOC) in water samples using only a mug with white interior, laminated piece of white paper, smartphone digital camera, and free computer app.
The ...
An entropy–enthalpy co-driven independent dual-mode biosensor

Analyst, 2025, 150,5166-5173
DOI: 10.1039/D5AN01020A, Paper
Xu-Fei Sun, Yuqi Luo, Xunan Dong, Hu Luo, Ke-Jing Huang
An entropy–enthalpy co-driven independent PEC-FL dual-mode biosensor is presented.
The content of this RSS Feed (c) The Royal Society of Chemistry
A bioelectronic nose with a flexible and implantable neural interface for odor detection and tobacco evaluation

Analyst, 2025, 150,5320-5329
DOI: 10.1039/D5AN00867K, Paper
Fan Wu, Jiale Wang, Wei Zhang, Yajie Zhang, Haoting Zhang, Zhichao Huang, Qifei Wang, Hao Wan, Ping Wang, Qunchen Yuan, Liujing Zhuang
A flexible, implantable bioelectronic nose records in vivo odor-evoked neural signals to achieve high-accuracy odor recognition and tobacco classification, offering an objective alternative for sensory evaluation.
The content of this RSS Feed (c) The Royal Society of Chemistry
Effect of AFM-based electrical stimulation on the electrophysiological and mechanical characteristics of cardiomyocytes

Analyst, 2025, 150,5309-5319
DOI: 10.1039/D5AN00503E, Paper
Jianjun Dong, Bowei Wang, Jinhong Fu, Yan Li, Tianzhu Yu, Xia Wang, Fengyan Hou, Junxi Wang, Zuobin Wang
Effects of electric field intensity, voltage frequency and DC current on cardiomyocytes’ mechanical and electrophysiological properties are studied by AFM; This work aids in simulating an in vitro electric environment for their growth and maturation.
The content of this RSS Feed (c) The Royal Society of Chemistry
TdT/Cas12a cascade amplification biosensor for sensitive ALP activity detection

Analyst, 2025, 150,5330-5337
DOI: 10.1039/D5AN00938C, Paper
Chengbin Pei, Bei Yan, Yan Wang, Ting Chen, Kunhao Du, Lianghong Ma, Juan Wang
This biosensor achieves single-cell ALP detection in cervical cancer lysates via TdT/CRISPR-Cas12a.
The content of this RSS Feed (c) The Royal Society of Chemistry
An overview of utilising photo-tunable thiophene scaffolds as luminogens for chemical and biological sensing: progress and prospects

Analyst, 2025, 150,5124-5141
DOI: 10.1039/D5AN01012H, Critical Review
Open Access Open Access
Aakash Venkatesan, Anila Rose Cherian, Aatika Nizam
A thiophene-based fluorescent probe system integrating electron donor, fluorophore, and recognition units enables effective ICT and PET mechanisms, demonstrating high sensitivity, selectivity, and specificity for chemical and biological sensing.
The content of th...
A multifunctional probe for optical and electrochemical detection of hydrogen sulfide and real-time selective fungal imaging

Analyst, 2025, 150,5245-5261
DOI: 10.1039/D5AN00783F, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ranjana M., Namita N. Kashyap, Dhanya Sunil, Anshuman Bera, Prajoy Kumar Mitra, Prakash Peralam Yegneswaran, Sudhakar Y. N., Dinesh Upadhya, Suresh D. Kulkarni, Sivaranjana Reddy Vennapusa
This study reports the synthesis of SNN, a fluorophore for selective H2S detection and real-time imaging of Candida albicans.
The content of this RSS ...
Hypochlorite-activated analyte-replacement fluorogenic probes for minute-level fast detection of acute kidney injury

Analyst, 2025, 150,5142-5146
DOI: 10.1039/D5AN00859J, Communication
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Tingfei Xie, Jiahui Chen, Xiaolu Sui, Yanzi Zhang, Jiqiang Liu, Jinxin Zhang, Xuechuan Hong, Daoyong Jiang, Pengfei Zhang, Jihong Chen
A sample-to-answer approach for minute-level fast detection acute kidney injury has been developed by using an analyte replacement near-infrared fluorogenic probe, which does not require complex ...
Optimisation of electron-induced dissociation parameters for molecular annotation of glycerides and phospholipids in fast LC-MS

Analyst, 2025, 150,5201-5211
DOI: 10.1039/D5AN00567A, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Vincen Wu, Abraham Moyal, Alaa Othman, Nicola Zamboni
We optimized LC-EIEIO-MS conditions to enable rapid and detailed lipid structural annotation. This approach allows routine identification of lipid classes, sn-positions, and carbon double bond locations within chromatographic timescales.
The content of this RSS Feed (c) The Royal Soci...
Lectin-enabled glycan signature of small extracellular vesicles by surface-enhanced Raman spectroscopy

Analyst, 2025, 150,5274-5285
DOI: 10.1039/D5AN00823A, Paper
Wei Zhang, Edward S. X. Moh, Mingkai Wu, Nicolle H. Packer, Yuling Wang
Glycan profiling of small extracellular vesicles via lectin-based surface-enhanced Raman spectroscopy (SERS) nanotags and CD63 antibody-coated magnetic beads.
The content of this RSS Feed (c) The Royal Society of Chemistry
Ratiometric detection of human serum albumin using an aggregation-induced enhanced emission-conjugated polyelectrolyte and a prototype smartphone device

Analyst, 2025, 150,5351-5361
DOI: 10.1039/D5AN00878F, Paper
Moirangthem Anita Chanu, Dheeraj Dineshbhai Khubchandani, Laxmi Raman Adil, Priyam Ghosh, Parameswar Krishnan Iyer
A novel AIEE-conjugated polymer was designed from an ACQ molecular system. The polymers’ emission was controlled by charge transfer state of the monomers. The AIEE polymer was modified into AIEE -polyelectrolyte and detect albumin ratiometrically.
The content of this RSS Feed (c) The Royal Society of Chemistry
Identifying and minimizing primary sources of temporal broadening in online affinity micro free-flow electrophoresis

Analyst, 2025, 150,5236-5244
DOI: 10.1039/D5AN00796H, Paper
Gretchen S. Burke, Michael T. Bowser
Affinity μFFE offers continuous, comprehensive separations for real-time measurement of peptides in dynamic biological systems. Here we optimize the response time of the assay addressing broadening in the incubation capillary and surface adsorption.
The content of this RSS Feed (c) The Royal Society of Chemistry
Ratiometric and simultaneous electrochemical analysis of uric acid and xanthine using poly(methylene blue) and reduced graphene oxide nanocomposite-modified screen-printed electrode

Analyst, 2025, 150,5212-5222
DOI: 10.1039/D5AN00863H, Paper
Geun Dae Kim, Sang Hyun Cho, Gi-Ja Lee
Ratiometric PMB/rGO-CNT SPCE affords simultaneous UA and XT quantification by SWV. The PMB internal peak stabilizes signals and supports reliable performance in human serum.
The content of this RSS Feed (c) The Royal Society of Chemistry
Generative Adversarial Network-driven high-resolution Raman spectral generation for accurate molecular feature recognition

Analyst, 2025, 150,5262-5273
DOI: 10.1039/D5AN00354G, Paper
Vikas Yadav, Abhay Kumar Tiwari, Soumik Siddhanta
GAN-driven generation of high-resolution Raman spectra from a low-resolution spectrometer for barcode-based molecular feature recognition.
The content of this RSS Feed (c) The Royal Society of Chemistry
β-Carboline platform-based novel fluorescent probes for the selective detection of zinc ions: synthesis, live-cell imaging and computational studies

Analyst, 2025, 150,5223-5235
DOI: 10.1039/D5AN00807G, Paper
Muhammad Ashraf, Mochamad Lutfi Firmansyah, Safwat Abdel-Azeim, Raden J. K. Susilo, Suhailah Hayaza, Nisar Ullah
Three novel fluorescent probes based on the β-carboline skeleton were synthesized for the selective detection of zinc ions in aqueous solution and the imaging of living cells.
The content of this RSS Feed (c) The Royal Society of Chemistry
Coupling a target-triggered hybridization chain reaction to a glucose/oxygen biofuel cell for sensitive self-powered detection of ochratoxin A

Analyst, 2025, 150,5303-5308
DOI: 10.1039/D5AN01003A, Paper
Shihan Liu, Shihua Wang, Wenfang Deng, Qingfang Zhang, Yueming Tan
Sensitive self-powered detection of ochratoxin A is achieved by coupling a target-triggered hybridization chain reaction to a glucose/oxygen biofuel cell.
The content of this RSS Feed (c) The Royal Society of Chemistry
Pirarubicin determination with impedimetric and voltammetric DNA sensors based on poly(Nile Blue) electropolymerized from deep eutectic solvents

Analyst, 2025, 150,5286-5302
DOI: 10.1039/D5AN01006C, Paper
Kadriya Vakhidova, Anastasia Goida, Tatiana Krasnova, Rezeda Shamagsumova, Vladimir Evtugyn, Anna Porfireva
The phenoxazine dye Nile Blue electropolymerized from the deep eutectic solvents was used for the first time as a constituent of DNA sensors for voltammetric and impedimetric determination of the anthracycline medication pirarubicin.
The content of this RSS Feed (c) The Royal Society of Chemistry
Global analysis of sedimentation velocity data sets from multiwavelength analytical ultracentrifugation experiments using enhanced regularisation techniques

Analyst, 2025, 150,5147-5165
DOI: 10.1039/D5AN00793C, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Christina Spruck, Lukas Pflug, Johannes Walter
HDR-SVFIT is developed as a tool for the fast and accurate global analysis of multiwavelength data sets from analytical ultracentrifugation.
The content of this RSS Feed (c) The Royal Society of Chemistry
Update on the microwave-assisted saponification conditions for mineral oil hydrocarbons determination in fats and oils

Analyst, 2025, 150,5190-5200
DOI: 10.1039/D5AN00701A, Paper
Aleksandra Gorska, Donatella Ferrara, Paula Albendea, Chiara Emilia Cordero, Giorgia Purcaro
Microwave-assisted saponification/extraction conditions for mineral oil hydrocarbons analysis in fats and oils were reoptimized to enable efficient saponification of hydrogenated fats while minimizing variability in internal standard recoveries.
The content of this RSS Feed (c) The Royal Society of Chemistry