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Megabase-scale human genome rearrangement with programmable bridge recombinases

Science, Ahead of Print.

— Nicholas T. Perry, Liam J. Bartie, Dhruva Katrekar, Gabriel A. Gonzalez, Matthew G. Durrant, James J. Pai, Alison Fanton, Juliana Q. Martins, Masahiro Hiraizumi, Chiara Ricci-Tam, Hiroshi Nishimasu, Silvana Konermann, Patrick D. Hsu 2025-09-25 06:18:42

Neural basis of cooperative behavior in biological and artificial intelligence systems

Science, Ahead of Print.

— Mengping Jiang, Linfan Gu, Mingyi Ma, Qin Li, Jonathan C. Kao, Weizhe Hong 2025-09-25 06:19:01

Asynchronous subunit transitions prime acetylcholine receptor activation

Science, Ahead of Print.

— Mackenzie J. Thompson, Christian J. G. Tessier, Anna Ananchenko, Camille Hénault, Johnathon R. Emlaw, François Dehez, Eleftherios Zarkadas, Corrie J. B. daCosta, Hugues Nury, John E. Baenziger 2025-10-02 05:58:42

A human pan-disease blood atlas of the circulating proteome

Science, Ahead of Print.

— María Bueno Álvez, Sofia Bergström, Josefin Kenrick, Emil Johansson, Mikael Åberg, Murat Akyildiz, Ozlem Altay, Hilda Sköld, Konstantinos Antonopoulos, Emmanouil Apostolakis, Yasin Hasan Balcioglu, Anna Bergström, Göran Bergström, Sophia Björkander, Suzanne Egyhazi Brage, Petter Brodin, Lynn Butler, Sara Cajander, Hanna Danielsson, Murat Dayangac, Gizem Dinler-Doganay, Levent Doğanay, Gunilla Enblad, Malin Enblad, Linn Fagerberg, Sara Falck-Jones, Anna Färnert, Mattias Forsberg, La... 2025-10-09 06:02:19

The functional landscape of coding variation in the familial hypercholesterolemia gene LDLR

Science, Ahead of Print.

— Daniel R Tabet, Atina G Coté, Megan C Lancaster, Jochen Weile, Ashyad Rayhan, Iosifina Fotiadou, Nishka Kishore, Roujia Li, Da Kuang, Jennifer J. Knapp, Carmela Serio Carrero, Olivia Taverniti, Anna Axakova, Jack M.P. Castelli, Mohammad Majharul Islam, Shahin Sowlati-Hashjin, Aanshi Gandhi, Ranim Maaieh, Michael Garton, Kenneth Matreyek, Douglas M Fowler, Mafalda Bourbon, Simon G. Pfisterer, Andrew M. Glazer, Brett M Kroncke, Victoria N. Parikh, Euan A. Ashley, Joshua W. Knowles, Melina Clau... 2025-10-30 05:59:00

The origin of hepatocellular carcinoma depends on metabolic zonation

Science, Ahead of Print.

— Jason Guo, Roger Liang, Andrew Chung, Zhijie Li, Boyuan Li, Eric Chen, Lin Li, Jingjing Wang, Meng-Hsiung Hsieh, Ivy Xiangyi Fang, Benjamin Kroger, Yunguan Wang, Min Zhu, Xiongzhao Ren, Greg Mannino, Yuemeng Jia, Yonglong Wei, Stephen Moore, Daniel J. Siegwart, Stephen S. Chung, Zixi Wang, Tripti Sharma, Suman Komjeti, Yi Han, Purva Gopal, Guanghua Xiao, Tao Wang, Hao Zhu 2025-11-06 06:59:18

Experimental evidence for nodal superconducting gap in moiré graphene

Science, Ahead of Print.

— Jeong Min Park, Shuwen Sun, Kenji Watanabe, Takashi Taniguchi, Pablo Jarillo-Herrero 2025-11-06 06:59:18

Cryo–electron microscopy visualization of RAD51 filament assembly and end-capping by XRCC3-RAD51C-RAD51D-XRCC2

Science, Ahead of Print.

— Luke A. Greenhough, Lorenzo Galanti, Chih-Chao Liang, Simon J. Boulton, Stephen C. West 2025-11-06 06:59:18

Postdomestication selection of MKK3 shaped seed dormancy and end-use traits in barley

Science, Ahead of Print.

— Morten E. Jørgensen, Dominique Vequaud, Yucheng Wang, Christian B. Andersen, Micha Bayer, Amanda Box, Katarzyna B. Braune, Yuanyang Cai, Fahu Chen, Jose A. Cuesta-Seijo, Haoran Dong, Geoffrey B. Fincher, Zoran Gojkovic, Zihao Huang, Benjamin Jaegle, Sandip M. Kale, Flavia Krsticevic, Pierre-Marie Le Roux, Antoine Lozier, Qiongxian Lu, Martin Mascher, Emiko Murozuka, Shingo Nakamura, Martin Ude Simmelsgaard, Pai R. Pedas, Pierre A. Pin, Dagmara Podzimska-Sroka, Kazuhiro Sato, Manuel Spannagl,... 2025-11-06 06:59:18

Duck-billed dinosaur fleshy midline and hooves reveal terrestrial clay-template “mummification”

Science, Ahead of Print.

— Paul C. Sereno, Evan T. Saitta, Daniel Vidal, Nathan Myhrvold, María Ciudad Real, Stephanie L. Baumgart, Lauren L. Bop, Tyler M. Keillor, Marcus Eriksen, Kraig Derstler 2025-10-23 06:00:36

Different repair pathways support intact or truncated insertions by R2 retrotransposon protein

Science, Ahead of Print.

— Jeremy J. R. McIntyre, Connor A. Horton, Kathleen Collins 2025-11-13 07:00:24

Recurrent acquisition of nuclease-protease pairs in antiviral immunity

Science, Ahead of Print.

— Owen T. Tuck, Jason J. Hu, Santiago C. Lopez, Benjamin A. Adler, Claire E. O’Brien, Kendall Hsieh, Charlotte Meredith, Kenneth J. Loi, Peter H. Yoon, Erin E. Doherty, Arushi Lahiri, Jennifer A. Doudna 2025-11-13 07:00:56

A whole-brain single-cell atlas of circadian neural activity in mice

Science, Ahead of Print.

— Katsunari Yamashita, Fukuaki L. Kinoshita, Shota Y. Yoshida, Katsuhiko Matsumoto, Tomoki T. Mitani, Hiroshi Fujishima, Yoichi Minami, Eiichi Morii, Rikuhiro G. Yamada, Seiji Okada, Hiroki R. Ueda 2025-11-13 07:01:18

Termination of the integrated stress response

Science, Ahead of Print.

— Claudia De Miguel, Sigurdur R. Thorkelsson, Agnieszka Fatalska, George Hodgson, Chao Wang, Anne Bertolotti 2025-11-13 07:00:00

Pan-family pollen signals control an interspecific stigma barrier across Brassicaceae species

Science, Ahead of Print.

— Yunyun Cao, Xiaoshuang Cui, Yinqing Yang, Lianhui Pan, Fei Yang, Shuyan Li, Dandan Wu, Yuelan Ding, Rui Chen, Nan Wang, Shangjia Liu, Zhaojing Ji, Yuxuan Zhao, Yue Chen, Rui Sun, Shiyu Xian, Lin Yang, Jiyun Hui, Ru Li, Tong Zhang, Shengwei Dou, Gengxing Song, Xiaochun Wei, Yuxiang Yuan, XiaoWei Zhang, Mingming Chen, Xihai Sun, Hen-Ming Wu, Alice Y. Cheung, Qiaohong Duan 2025-11-20 06:59:04

A global screen for magnetically induced neuronal activity in the pigeon brain

Science, Ahead of Print.

— Gregory C. Nordmann, Spencer D. Balay, Thamari N. Kapuruge, Marco Numi, Christoph Leeb, Simon Nimpf, E. Pascal Malkemper, Lukas Landler, David A. Keays 2025-11-20 06:59:04

Intracellular competition shapes plasmid population dynamics

Science, Ahead of Print.

— Fernando Rossine, Carlos Sanchez, Daniel Eaton, Johan Paulsson, Michael Baym 2025-11-20 06:59:04

Characterizing transport in a quantum gas by measuring Drude weights

Science, Ahead of Print.

— Philipp Schüttelkopf, Mohammadamin Tajik, Nataliia Bazhan, Federica Cataldini, Si-Cong Ji, Jörg Schmiedmayer, Frederik Møller 2025-11-27 07:00:00

Synergy between regulatory elements can render cohesin dispensable for distal enhancer function

Science, Ahead of Print.

— Karissa L. Hansen, Annie S. Adachi, Luca Braccioli, Smit Kadvani, Ryan M. Boileau, Moreno Martinovic, Bozhena Pokorny, Rini Shah, Erika C. Anderson, Kaite Zhang, Irié Carel, Kenya Bonitto, Robert Blelloch, Geoffrey Fudenberg, Elzo de Wit, Elphège P. Nora 2025-11-27 07:00:00

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2

Science, Ahead of Print.

— Martin S. Taylor, Maggie Chen, Matthew Hancock, Maximilian Wranik, Bryant D. Miller, Timothy R. O’Meara,, Brad A. Palanski, Scott B. Ficarro, Brian J. Groendyke, Yufei Xiang, Kazuma T. Kondo, Karen Y. Linde-Garelli, Michelle J. Lee, Dibyendu Mondal, Daniel Freund, Samantha Congreve, Kaay Matas, Maximiliaan Hennink, Kera Xibinaku, Max L. Valenstein, Trevor van Eeuwen, Jarrod A. Marto, Andrej Sali, Yi Shi, Nathanael S. Gray, David M. Sabatini, Nam Chu, Kacper B. Rogala, Philip A. Cole 2025-11-27 07:00:00

Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration

Science, Ahead of Print.

— Mamta Singla, Yu Xin Wang, Elena Monti, Yudhishtar Bedi, Pranay Agarwal, Shiqi Su, Sara Ancel, Maiko Hermsmeier, Nitya Devisetti, Akshay Pandey, Mohsen Afshar Bakooshli, Adelaida R. Palla, Stuart Goodman, Helen M Blau, Nidhi Bhutani 2025-11-27 07:00:00

Macrophage MR1 antigen presentation promotes MAIT cell immunity and lung microbiota modulation

Science, Ahead of Print.

— Jieru Deng, Yuting Yan, Xiaoyue Zhang, Calum J. Walsh, Emmanuel Montassier, Debajyoti Sinha, Huimeng Wang, Atieh Mousavizadeh, Mitra Ashayeripanah, Jeffrey Y. W. Mak, Hui-Fern Koay, Tobias Poch, Yannick O. Alexandre, Scott N. Mueller, Ajithkumar Vasanthakumar, Tim P. Stinear, Vanta J. Jameson, Alexis Perez-Gonzalez, Jenny Kingham, Tri Giang Phan, Nikita Potemkin, Lachlan Dryburgh, Jan Schroeder, David P. Fairlie, Laura K. Mackay, Zhenjun Chen, Laura Cook, Abderrahman Hachani, Alexandra J. Cor... 2025-12-04 07:00:02

A diminutive tyrannosaur lived alongside Tyrannosaurus rex

Science, Ahead of Print.

— Christopher T. Griffin, Jeb Bugos, Ashley W. Poust, Zachary S. Morris, Riley S. Sombathy, Michael D. D’Emic, Patrick M. O’Connor, Holger Petermann, Matteo Fabbri, Caitlin Colleary 2025-12-04 07:00:02

Multispecies grasslands produce more yield from lower nitrogen inputs across a climatic gradient

Science, Ahead of Print.

— James O’Malley, John A. Finn, Carsten S. Malisch, Matthias Suter, Sebastian T. Meyer, Giovanni Peratoner, Marie-Noëlle Thivierge, Diego Abalos, Paul R. Adler, T. Martijn Bezemer, Alistair D. Black, Åshild Ergon, Barbara Golińska, Guylain Grange, Josef Hakl, Nyncke J. Hoekstra, Olivier Huguenin-Elie, Jingying Jing, Jacob M. Jungers, Julie Lajeunesse, Ralf Loges, Gaëtan Louarn, Andreas Lüscher, Thomas Moloney, Christopher K. Reynolds, Ievina Sturite, Ali Sultan Khan, Rishabh Vishwakarma,... 2025-12-04 07:00:02

Spatial and morphological organization of mitochondria in neurons across a connectome

Science, Ahead of Print.

— Garrett Sager, Paul Pfeiffer, Heng Wu, Fabian Pallasdies, Robert Gowers, Snusha Ravikumar, Elizabeth Wu, Daniel Colón-Ramos, Susanne Schreiber, Damon A. Clark 2025-12-11 06:59:13

ARF3-mediated auxin signaling is essential for sex determination in cucumber

Science, Ahead of Print.

— Lijie Han, Min Li, Chuang Li, Bosi Zhao, Zhongyi Wang, Ye Liu, Zhihan Liu, Yafei Huang, Liu Liu, Haoran Geng, Yuting He, Jingyu Guo, Shaoyun Wang, Liming Wang, Chaoheng Gu, Junjun Shen, Zheng Li, Jianyu Zhao, Zhaoyang Zhou, Xiaolan Zhang 2025-12-11 06:59:13

Progressive eastward rupture of the Main Marmara fault toward Istanbul

Science, Ahead of Print.

— Patricia Martínez-Garzón, Xiang Chen, Dirk Becker, Sebastián Núñez-Jara, Recai Feyiz Kartal, Elif Türker, Georg Dresen, Yehuda Ben-Zion, Jorge Jara, Fabrice Cotton, Filiz Tuba Kadirioglu, Tuğbay Kiliç, Marco Bohnhoff 2025-12-11 06:59:13

Structure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum

Science, Ahead of Print.

— Alexander M. Scrutton, Nayanika Sengupta, Josip Ivica, Imogen Stockwell, Sew Peak-Chew, Bishal Singh, Kunimichi Suzuki, Veronica T. Chang, Stephen H. McLaughlin, James M. Krieger, A. Radu Aricescu, Ingo H. Greger 2025-12-11 06:59:13